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Antidepressant Drugs and Headache: Is There a Hyperlink?

Da Hee Han, PharmD Might 03, 2018 ...


Might 03, 2018

Risk ratios of headache reported as an adverse event were calculated and compared to placebo

Threat ratios of headache reported as an hostile occasion have been calculated and in comparison with placebo

A meta-analysis revealed within the Journal of Affective Problems discovered that stories of headache after beginning therapy with second-generation antidepressants “usually tend to be coincidental than a treatment-emergent aspect impact of those drugs.”

Researchers aimed to evaluate the danger of headache linked to frequent antidepressants and the affect of remedy class, pharmacodynamics, and dosage related to this threat. They recognized randomized, double-blind, placebo-controlled trials evaluating the efficacy of second-generation antidepressants in adults with nervousness, despair, or obsessive-compulsive problems. Threat ratios of headache reported as an hostile occasion have been calculated and in comparison with placebo. Subgroup analyses additional examined the consequences of drug class, dosage, indication, and receptor affinity on the danger of headache. 

In comparison with placebo, selective serotonin reuptake inhibitors (SSRIs) have been related to a considerably greater threat of headache (threat ratio [RR] 1.06, 95% CI: 1.00 to 1.13; P =.045). No important distinction within the threat of headache was noticed between SSRIs and serotonin norepinephrine reuptake inhibitors (SNRIs) (RR zero.97, 95% CI: zero.88 to 1.06; P =.63). Furthermore, there was no important distinction within the threat of headache with use of second-generation antidepressants when stratified by indication, pharmacological properties, and drug dosage. 

Of the evaluated antidepressants, bupropion (RR 1.22, 95% CI: 1.06 to 1.41; P =.zero06) and escitalopram (RR 1.18, 95% CI: 1.01 to 1.37; P =.04) demonstrated a major affiliation with an elevated threat of headache vs placebo. 

Associated Articles

The authors observe that along with doable reporting bias, “the small variety of research that examined unwanted effects inside fixed-dose trials might have restricted the ability to look at the affiliation between remedy dosing and threat of headache.”

For extra info go to jad-journal.com.

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Is there plastic in your pills?


Is there plastic in your pills?
I frequently have to add naproxen or ibuprofen to ease the arthritis in my hips and knees. I have been having trouble with constipation and suspect that the tramadol is contributing. Do you have any recommendations for dealing with this besides laxatives?
Read more on Charlotte Observer

How can I diagnose a shoulder injury based on symptoms and not an MRI? is there a good website or anything?


How can I diagnose a shoulder injury based on symptoms and not an MRI? is there a good website or anything?
i had a freak accident with a dumbbell and i experience pain in certain motions when i move my arm, and when i put my elbow above my head and push it towards my back, i can feel real pain and discomfort in my front deltoid of my shoulder. i just want to know if it is the muscle thats sprained, tendon, or the rotator cuff…
i just payed for an MRI last year for a different injury, and i don’t want to pay for it again if i don’t have to…. because that injury seemed more serious and the MRI showed nothing after the steroid shots except for slight atrophy

Best answer(s):

Answer by love 2 cheer
The internet can not tell you whats wrong. You need to go back to a doctor and if they say you need an MRI that so be it.

Answer by William
You could have muscle strained around shoulder & elbow region. A muscle strain is an injury to either a muscle or a tendon, the tissue that connects muscles to bones. Depending on the severity of the injury, a strain may be a simple overstretch of the muscle or tendon, or it can result in a partial or complete tear.

On how to diagnose, you have diagnosed yourself by raised up elbow above head & push toward back. You will feel pain around deltoid muscle due to overstretched of inflamed muscle. Another sign of sprained shoulder is swelling around shoulder.

Early treatment of a sprained shoulder can help to speed recovery and minimize the symptoms & signs. Here are a few simple treatment steps to follow should you sustain a sprained ankle.

1. REST – Take a few days off of your routine exercise. i.e., do not use your dumbbell. You don’t have to be inactive, but be sure the shoulder is being rested.

2. ICE – This can be done several times a day for 15-20 minutes. This will keep the swelling to a minimum. Do NOT ice for more than 20 minutes, it will do more damage than good. Please use a small tower to cover the ICE before you place it onto your shoulder. (to prevent direct ICE burn to your skin).

3. COMPRESSION – Use compression when elevating a sprain or strain in early treatment. Using an Ace bandage, wrap the area overlapping the elastic wrap by one-half of the width of the wrap. The wrap should be snug, but not cutting off circulation to the extremity.

(i) NSAIDs pain killer. Here is a list of NSAIDs for you to choose.
– aspirin Salsalate (Amigesic)
– celecoxib (Celebrex),
– diclofenac (Voltaren),
– etodolac (Lodine),
– ibuprofen (Motrin),
– indomethacin (Indocin),
– ketoprofen (Orudis),
– ketorolac (Toradol),
– nabumetone (Relafen),
– naproxen (Aleve, Naprosyn),
– oxaprozin (Daypro),
– piroxicam (Feldene),
– sulindac (Clinoril),
– tolmetin (Tolectin), and
– mefenamic acid (Ponstan)
I suggest you take mefenamic acid. This medicine should be taken with or after food to help reduce irritation to the stomach.

You do not need a MRI scan to diagnose fracture bone. If pain persist after 2-3 days of NSAIDs medication, you may consider to do a X-ray. (to check for any potential fracture).

Is there cholestrol to reduce side effects of medication?


Are there any side effects of medications to reduce cholestrol?
Best Answer (s):

by Gary F – probably
simply not high cholestrol get in the first place.

Answer by Bob H Reply
I take Vitorin, and I know nothing about it. OTOH, I do not know if they are doing no good either.

Reply kelumnk
Hello, I am a dcotor .. Statins are a group of drugs that are commonly used to lower cholesterol .. There are currently six statins on the market: atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), rosuvastatin (Crestor) A seventh statin, cerivastatin (Baycol) was out of the market in the summer of 2001 because of the potentially serious side effects entfernt.Was are the common side effects of statins, the most common side effects of statins are gastrointestinal – nausea, gas, upset stomach. (Sleep disorders seem to be more frequent with atorvastatin and simvastatin.) Less common are headaches, dizziness, rash, and insomnia statins cause increases in liver enzymes in 1 of 100 patients. While blood tests should be reviewed after a few weeks of treatment, there is little evidence that statins ever cause serious or permanent liver damage.however if liver enzyme levels is more than 3 times normal and holds remains high, then the drug must be stopped. otherwise it may be continued .. statins cause muscle disease producing muscle weakness, and sometimes pain, in 1 of 1,000 patients. If muscle destruction is widespread, can lead to kidney failure and death führen.Eine excessive and potentially fatal form of muscle disease is the reason cerivastatin (Baycol) was from the market genommen.Rosuvastatin was also seen to have the severe form of muscle disease but only with the 80-mg dose (doses up to 40 mg only approved.) Rosuvastatin was also reported that a poorly explains kidney disease in some patients with 80 mg of lead (not approved) dosieren.Fühlen free to me to write, or visit Siewww.medicguide.orgdies one side of me and my doctor friends is done to … to answer all your health questions for free

Answer by Shelly
Yes, there will be an imbalance of your T1 & T2s in your gut.

Answer by Susan Yarrawonga
A common side effect is sore muscles.

What is Lisinopril? is it safe to take it? Are there any side effects to use it?


What is Lisinopril? is it safe to take it? Are there any side effects to use it?
Best Answer (s):

Extra Stuff Reply
This is a medication that is usually prescribed for high blood pressure, but be careful and check it often when you first start to use it. WalMart and similar stores sell home economic units tract of BP hold.

Answer by Sunny
There is a (ACE) inhibitors, especially in the treatment of hypertension, congestive heart failure and heart attacks used, and also in preventing renal and retinal complications of diabetes …

Reply xjoizey
It’s only for hypertension. Prescribed by a physician and as directed it is safe.

Answer by STUART taken
Lisinopril is an ACE inhibitor used primarily to treat high blood pressure. Lisinopril is the generic version of Zestril and Prinivil. http://lisinoprilsideeffects.comHerzinsuffizienz and heart attack patients the past, Lisinopril is used to treat people with high blood pressure eingesetzt.Dies the failures of side effects for each category of patients are einBluthochdruck – The following adverse reactions in more than 1% of patients occurred: Cough (most common) body weakness (asthenia), dizziness, lightheadedness, or fainting fatigue extreme low blood pressure nausea vomiting diarrhea headache dizziness