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Study Results of the Effects of Sildenafil Citrate (brand name: Viagra) Announced


Study Results of the Effects of Sildenafil Citrate (brand name: Viagra) Announced

(PRWEB) July 7, 2005

A company spokesman, Michael Taylor, said, “Sildenafil Citrate (brand name: Viagra) is used to treat erectile dysfunction (impotence) and it may also be used for purposes other than those listed in a medication guide. Although Sildenafil Citrate is not indicated for use by women, it is in the FDA pregnancy category B. This means that Sildenafil Citrate (brand name: Viagra) is not expected to be harmful to an unborn baby. Sildenafil Citrate is for the benefit of women but should not be taken by women.”

The company spokesman said that all of the products available at their web store http://www.dr-viagra.com are manufactured to Good Manufacturing Practices standards and are the same formulas and ingredients as their brand name counterparts’ at large discounts.

The company spokesman also said that based on a study of 228 men 94.7% had success with Sildenafil, each taking 100 mg at least 2 hours after eating. For most men, Sildenafil works in just 30 minutes or less.

Michael Taylor informs that no medicine is for everyone. If you use nitrate drugs, often used for chest pain (known as angina), don’t take VIAGRA. Taking these drugs at the same time could cause your blood pressure to drop to an unsafe level. Talk with your doctor first. Make sure you are healthy enough to have sex. If you have chest pain, nausea, or other discomforts during sex, seek medical help right away. Although erections lasting for more than four hours may occur rarely with all ED treatments in this drug class, it is important to seek immediate medical attention. Erections lasting more than six hours can result in long-term loss of potency.

http://www.dr-viagra.com also offers non internet users the opportunity to save money on their Sildenafil and many other generic drugs by calling their toll free sales number, 877-247-9304 twenty four hours a day.


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Sildenafil (Viagra) and the Heart


Sildenafil (Viagra) and the Heart

(PRWEB) January 22, 2005

Impotence – the preferred term is now erectile dysfunction is a common problem affecting between 10 to 30 million men in the United States. (Furlow WL. Prevalence of impotence in United States. Med Aspects Hum Sex 1985; 10:13-6).

Worldwide, more than 100 million men are estimated to have some degree of erectile dysfunction. (allyourpills) The introduction of sildenafil (Viagra) has been a valuable contribution to many patients suffering from erectile dysfunction. There have now been 3.6 million prescriptions written for sildenafil.

Sildenafil acts as a selective inhibitor of cyclic GMP-specific phosphodiesterase type 5, resulting in smooth muscle relaxation, vasodilation, and enhanced penile erection. The vasodilating action of sildenafil affects both the arteries and the veins. (Utiger RD. A pill for impotence (editorial). N Engl J Med 1998; 338:1458-9).

Reported side effects in the normal healthy population are usually associated with vasodilation. These include headaches (16%), flushing (10%), rhinitis (4%), dizziness (2%), hypotension (2%), and postural hypotension (2%). Other side effects include dyspepsia (7%), blue-green color-tinged vision and blurred vision (3%).

Although their incidence is small, serious cardiovascular events, including significant hypotension can occur in certain population at risk. Most at risk are individuals who are concurrently taking organic nitrates. (allyourpills)

In U.S.A., approximately 5.5 million men take nitrates on a regular basis for angina pectoris, and another half million will experience a heart attack annually and are potential candidates for nitrate therapy. Sildenafil is potentially contraindicated in these 6 million patients. All patients taking either sildenafil or nitrates must be warned of the contraindications and potential consequences of taking sildenafil within 24-hour interval after taking a nitrate preparation, including sublingual nitroglycerin.

Sildenafil is predominantly metabolized by both the P 450 2C9 pathway and the P450 3A4 pathway. Thus, potent inhibitors of the P450 3A4 pathway may increase the plasma concentrations of sildenafil and its pharmacological effects. Cimetidine and erythromycin are commonly prescribed drugs that inhibit the P 450 3A4 pathway. The simultaneous administration of either of these agents significantly increases the plasma concentration of sildenafil; a lower initial dose (25 mg) should be considered in the coadministration of sildenafil to patients receiving either of these agents. (allyourpills)

Many drugs are metabolized by the P 450 3A4 pathway but are not inhibitors of the pathway. The coadministration of one of these drugs may lead to competitive inhibition of the metabolism of sildenafil.

Physicians should be aware of the potential interaction of such agents. The list of a commonly prescribed drugs metabolized via the P 450 3A4 pathway include: amiodarone, digoxin, diltiazem, losartan, nifedipine, atorvastatin, cerivastatin, lovastatin, simvastatin, and cisapride. (4) Patients with severe renal impairment (creatinine clearance 30 ml/min) have a reduced clearance of sildenafil. Thus, the duration of the effect of sildenafil in these patients will be prolonged and particular care should be taken in the administration of concomitant medications that may lower blood pressure.

Plasma concentrations of sildenafil and of its metabolites may be significantly increased in patients with hepatic dysfunction. Thus, the duration of activity of sildenafil may be prolonged and the extent of its effects enhanced. As in patients in renal dysfunction, the initiation of therapy at 25 mg rather than 50 mg may be appropriate in patients with hepatic dysfunction. Because the effects of sildenafil have not been evaluated in patients with bleeding disorders or in patients taking non aspirin antiplatelet agents (e.g. ticlopidine, clopidogrel or dipyridamole), caution should be experienced when the drug is administered in these clinical settings.(4)

What are the current recommendations for prescribing sildenafil to patients at risks? Sildenafil is absolutely contraindicated in patients taking any long-acting nitrates therapy or using short-acting nitrates because of the risk of developing potentially life-threatening hypotension. All patients taking organic nitrates, even if they have not asked for Viagra, should be informed about the nitrate-sildenafil hypotensive interaction. Similarly, patients must be warned of the contraindication of taking sildenafil in the 24-hour time interval after taking a nitrate preparation, including sublingual nitroglycerin.

Other patients in whom the use of sildenafil is potentially hazardous include those with active coronary ischemia, those with congestive heart failure and borderline low blood volume and low blood pressure status; those with complicated, multidrug, antihypertensive therapy regimens; and those taking medications that may affect the metabolic clearance of sildenafil. If patients are taking a combination of antihypertensive medications, they should be cautioned about the possibility of sildenafil-induced hypotension. Although firm data are lacking, pre-Viagra treadmill test to assess for the presence of stress-induced ischemia can be helpful. If the patient can achieve > 5 to 6 METS on an exercise tolerance test without demonstrating ischemia, the risk of ischemia during coitus without the added stress of a heavy meal or alcohol ingestion, is probably low. (allyourpills)

In patients with recurring mild angina after sildenafil use, other nonnitrate antianginal agents, such as ГѓВџ-blockers, should be considered. Patients taking sildenafil who have an acute myocardial infarction should be treated in the usual manner including, where appropriate, primary angioplasty or thrombolytics. The only difference is that nitrates are contraindicated for these patients.

In patients with unstable angina, therapy should include only non nitrate antianginal medications. To date, there is no evidence of significant interactions between sildenafil and heparin, ГѓВџ-blockers, calcium channel blockers, narcotics, or aspirin. These drugs can be used as appropriate. After 24 hours, nitrates may be administered if close monitoring is provided. In patients who inadvertently received nitrates while taking sildenafil and who manifest a severe hypotensive response, it is essential to have the capability to support the patient with fluid resuscitation and alpha-adrenergic agonists. (allyourpills)

Finally, whether the promise of sildenafil will be realized after many more men have been treated and the drug has been taken repeatedly for prolonged periods remains to be seen.


VocusВ©Copyright 1997-2010, Vocus PRW Holdings, LLC.
Vocus, PRWeb and Publicity Wire are trademarks or registered trademarks of Vocus, Inc. or Vocus PRW Holdings, LLC.