‘Marburg’ Tagged Posts

WRAIR scientific research evaluates security and immunogenicity of Marburg vaccine

The Walter Reed Military Institute of Analysis (WRAIR) this week administered the primary vaccine in a Part 1 scientific trial to judge the security...


The Walter Reed Military Institute of Analysis (WRAIR) this week administered the primary vaccine in a Part 1 scientific trial to judge the security and immunogenicity of a Marburg vaccine candidate in wholesome grownup volunteers.

The WRAIR research evaluates the VRC-MARADC087-00-VP vaccine, developed by the Vaccine Analysis Heart (VRC) of the Nationwide Institute of Allergy and Infectious Ailments (NIAID), Nationwide Institutes of Well being (NIH). The recombinant chimpanzee adenovirus kind Three-vectored Marburg virus vaccine candidate being examined is geared toward stimulating fast however sturdy immunity. This vaccination technique is taken into account optimum to guard each first-line well being staff and common populations in areas the place outbreaks happen.

“Given the latest lethal outbreak of Marburg virus in Uganda, there’s a vital have to develop a protected and efficient vaccine which has the potential to guard our troopers and the general public from this severe risk,” stated Lt. Col. Melinda Hamer, chief of the WRAIR Medical Trials Heart in Silver Spring, Md., the place the trial is being performed.

Forty wholesome, grownup volunteers shall be enrolled and assigned into one in every of two teams to judge completely different vaccine dosages. Volunteers shall be intently adopted over the course of roughly one yr after vaccination for security and immune system response.

The Marburg virus is in the identical household as Ebola and causes extreme hemorrhagic fever in people. Case fatality charges in Marburg outbreaks have ranged from 24% to 88%. The latest outbreak occurred in Uganda in 2017.

WRAIR performed the primary Ebola vaccine scientific trial in Africa in 2009, testing an early vaccine candidate additionally developed by the VRC at NIAID. Through the 2014 West Africa Ebola outbreak, WRAIR conceived of, after which initiated a Part I scientific trial of the VSV-EBOV vaccine candidate over a interval of simply 11 weeks at its CTC. WRAIR has performed six Ebola vaccine research thus far.

“This primary-in-human trial of the NIH vaccine is a part of an essential inter-agency effort by the US authorities to anticipate and counter rising infectious threats to the Individuals, each navy and civilian, at residence and overseas,” added Dr. Kayvon Modjarrad, the director of the Rising Infectious Ailments Department at WRAIR.