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Tips for Managing Perimenopausal Melancholy Now Obtainable

Posted in News on 6th September 2018

September 05, 2018

The panel notes that estrogen is not approved by the Food and Drug Administration to treat mood disturbance

The panel notes that estrogen is not approved by the Food and Drug Administration to treat mood disturbance

The first-ever guidelines for the evaluation and treatment of perimenopausal depression have been published by The North American Menopause Society in collaboration with the National Network on Depression Centers for Women and Mood Disorders Task Group. The new guidelines have been endorsed by the International Menopause Society and are currently available for review in the journal Menopause and the Journal of Women’s Health.

The 5 topics addressed by the 11-member expert panel include epidemiology, clinical presentation, therapeutic effects of antidepressants, effects of hormone therapy, and the effectiveness of other therapies (eg, psychotherapy, exercise, natural health products). “The reason these guidelines are needed is because depression during the perimenopausal phase can occur along with menopausal symptoms, and these 2 sets of symptoms are hard to tease apart, which makes it difficult for clinicians to appropriately treat these women,” said Dr Pauline Maki, professor of psychology and psychiatry in the University of Illinois at Chicago College of Medicine and co-lead author of the new guidelines. “Many women experience a new onset of depressive symptoms. If there is underlying low-level depression to begin with, perimenopause can increase the intensity of depressive symptoms.”

Regarding treatment, the panel recommends proven therapeutic options such as antidepressants, cognitive-behavioral therapy, and other psychotherapies as first-line therapies for major depressive episodes. When selecting an antidepressant, clinicians should consider the patient’s prior experience with these agents, as well as the possibility of adverse events and safety issues such as drug-drug interactions.

At usual doses, selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) have been shown to be effective and may also improve menopause-related issues such as vasomotor symptoms and pain. Desvenlafaxine, in particular, has proven efficacy based on large, placebo-controlled trials involving peri- and postmenopausal depressed women. In addition, sleep disturbance and night sweats should be factored into the treatment of menopause-related depression. 

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With regard to estrogen therapy, the guidelines state that the treatment is ineffective for depressive disorders in postmenopausal women, although there is some evidence to suggest that estrogen has antidepressant effects similar to that seen with antidepressant agents in depressed perimenopausal women. In women approaching menopause, hormonal contraceptives, used continuously, may improve depressive symptoms. The panel notes that estrogen is not approved by the Food and Drug Administration to treat mood disturbance and that most studies of hormone therapy as a treatment for depression examined the effects of unopposed estrogen; data on combined hormone therapy or for progestogens is inconclusive.

As for botanical and alternative approaches, there is insufficient evidence to recommend these treatments for depression related to perimenopause.

“There has been a need for expert consensus as well as clear clinical guidance regarding how to evaluate and treat depression in women during perimenopause,” said Dr Susan Kornstein, professor of psychiatry and obstetrics & gynecology at Virginia Commonwealth University and co-lead author of the guidelines. “These new clinical recommendations address this gap and offer much-needed information and guidance to healthcare practitioners so that they can provide optimal care and treatment for midlife women.”

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Can Omega-Three Fatty Acid Monotherapy Successfully Deal with Adolescent Despair?

Posted in News on 23rd July 2018

July 20, 2018

This text initially appeared on Psychiatry Advisor.

O3FA had no significant clinical advantages compared with placebo on any clinical feature.

O3FA had no vital medical benefits in contrast with placebo on any medical function.

Outcomes of a double-blind, placebo-controlled research printed within the Journal of Medical Psychiatry recommend that omega-Three fatty acids (O3FA) will not be superior to placebo as monotherapy for adolescents with main depressive dysfunction.

Adolescents (age 12-19 years; 57% women) identified with main depressive dysfunction had been randomly assigned to both O3FA (n=24) or placebo (n=27) for 10 weeks ( identifier: NCT00962598). Each brokers had been administered at an preliminary dose of 1.2 g/day, titrated as much as a most dose of three.6 g/day in zero.6-g/day increments each 2 weeks. Members weren’t taking any psychotropic drugs in the course of the research interval. Investigators captured melancholy severity utilizing clinician scores on the Youngsters’s Despair Ranking Scale-Revised and self-ratings on the Beck Scale for Suicide Ideation. Members had been additionally monitored for dietary consumption, research compliance, and antagonistic occasions. 

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O3FA had no vital medical benefits in contrast with placebo on any medical function, together with melancholy severity and ranges of anhedonia, irritability, and suicidality. Each teams reported enhancements in clinician-rated melancholy severity (O3FA, P<.001; placebo, P<.00) and in self-rated suicidality (O3FA, P<.001; placebo, P=.002) in the course of the research interval. Utilizing clinician-rated melancholy scale scores, 42.9% of O3FA recipients and 50% of placebo recipients had been categorized as “remedy responders,” though no vital variations in response ranges had been recognized between teams (P=.63). Each teams skilled related enhancements within the melancholy subcategories of irritability (each P<.001) and anhedonia (O3FA, P=.001; placebo, P<.001). No vital antagonistic occasions had been noticed for both treatment at any dose.

These outcomes problem present conceptions that O3FA monotherapy could also be efficient in treating adolescent main depressive dysfunction. Nevertheless, the small pattern measurement and heterogenous nature of the research inhabitants might have restricted this evaluation. Future research are essential to elucidate the exact benefits, if any, provided by O3FA remedy.


Gabbay V, Freed RD, Alonso CM, et al. A double-blind placebo-controlled trial of omega-Three fatty acids as a monotherapy for adolescent melancholy. J Clin Psychiatry. 2018;79(four):17m11596.

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Intranasal formulation of ketamine exhibits promise in speedy remedy of melancholy, suicidality

Posted in News on 17th April 2018

A nasal spray formulation of ketamine exhibits promise within the speedy remedy of signs of main melancholy and suicidal ideas, based on a brand new research printed on-line as we speak in The American Journal of Psychiatry (AJP).

The double-blind research in contrast the usual remedy plus an intranasal formulation of esketamine, a part of the ketamine molecule, to plain remedy plus a placebo for speedy remedy of signs of main melancholy, together with suicidality, amongst people at imminent suicide threat. The research concerned 68 members randomly assigned to one among two teams – both receiving esketamine or placebo twice per week for 4 weeks. All members continued to obtain remedy with antidepressants all through. The researchers checked out results at 4 hours after first remedy, at 24 hours and at 25 days.

The research was performed by researchers at Janssen Analysis and Improvement and Janssen Scientific Affairs, Titusville, N.J., and San Diego, and the Yale Faculty of Drugs, New Haven, Conn. They discovered a major enchancment in melancholy scores and decreased suicidal ideation within the esketamine group in comparison with the placebo group at 4 hours and at 24 hours. The esketamine results weren’t larger than the placebo at 25 days. The measurement of suicide threat took into consideration each the affected person’s and clinician’s views.

The outcomes of the research assist nasal spray esketamine as a potential efficient speedy remedy for depressive signs in sufferers assessed to be at imminent threat for suicide, based on the authors. Esketamine may very well be an vital remedy to bridge the hole that exists due to the delayed impact of most typical antidepressants. Most antidepressants take 4 to 6 weeks to develop into absolutely efficient.

This research was a proof-of-concept, part 2, research for esketamine; it should nonetheless undergo a part three research earlier than potential FDA approval. It was funded by Janssen Analysis and Improvement, LLC.

The authors warning that extra analysis is required on the potential for abuse of ketamine. That warning can also be the main target of an accompanying AJP editorial additionally printed on-line as we speak. Within the editorial, AJP Editor Robert Freedman, M.D., together with members of the AJP Editorial Board, word the recognized potential for abuse and current studies of abuse of prescribed ketamine. They focus on the necessity for added analysis regarding the abuse potential of ketamine throughout part three trials, akin to monitoring of sufferers’ craving and potential ketamine use from different sources.

Whereas it’s the accountability of physicians to offer a suicidal affected person with the fullest vary of efficient interventions, the AJP Editor’s word, “safety of the general public’s well being is a part of our accountability as properly, and as physicians, we’re accountable for stopping new drug epidemics.” The Editors recommend the necessity for broad enter within the improvement of efficient controls on the distribution and use of ketamine.

Freedman and colleagues argue that steps to manage the usage of ketamine wouldn’t be aimed toward stopping its use for useful functions however would enable for remedy to “proceed to be obtainable to these with want, whereas the inhabitants that’s at-risk for abuse is protected against an epidemic of misuse.”


Melancholy Therapy Initiation Amongst Newly Identified ‘Suboptimal’, Says Research

Posted in News on 14th February 2018
A total of 241,251 adults with newly diagnosed depression were assessed for this study

A complete of 241,251 adults with newly recognized melancholy have been assessed for this research

Regardless of the supply of efficient therapies for melancholy, many newly recognized people don’t provoke therapy within the three months following prognosis. The findings come from a brand new observational research revealed within the Journal of Normal Inner Medication

The research included sufferers (n=241,251) who have been newly recognized with melancholy (outlined as ICD-9 codes for melancholy, after 365 days with no melancholy prognosis or therapy) in a main care setting. The researchers outlined therapy initiation as those that had accomplished a psychotherapy go to or crammed a prescription for antidepressant treatment inside 90 days of prognosis. 

They discovered that solely 35.7% of people initiated therapy. The percentages of therapy initiation have been ≤30% decrease amongst Asians, non-Hispanic blacks, and Hispanics in comparison with non-Hispanic whites, after controlling for different variables. For people over the age of 60, the percentages of initiation have been half these of people below 44 years previous.

Initiation did rise in tandem with severity of melancholy, nevertheless it was nonetheless significantly low. Total simply 53% of those that scored ≥10 within the Affected person Well being Questionnaire-9 initiated therapy.

The authors write that whereas melancholy screening in main care continues to be a step in the correct course, the extent of therapy initiation stays ‘suboptimal’. “A greater understanding of affected person elements, and notably system-level elements, that affect therapy initiation is required to tell efforts by heath care techniques to enhance melancholy therapy engagement and to scale back disparities.”

DEPRESSION 11: Antidepressants (Placebo Effect)

Posted in Phenelzine on 8th June 2017