‘News’ Category

Perseris Now Obtainable for the Therapy of Schizophrenia in Adults

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Advantages of Simplified HCV Therapy Program Investigated

 

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Adcetris Plus Chemotherapy Accepted for Peripheral T-Cell Lymphoma

 

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Novel Antiviral Pimodivir Evaluated in Sufferers With Acute Uncomplicated Influenza A

 

November 16, 2018

Pimodivir is a novel nonnucleoside PB2 inhibitor.

Pimodivir is a novel nonnucleoside PB2 inhibitor.

Pimodivir, an investigational first-in-class inhibitor of influenza virus polymerase basic protein 2 (PB2), was found to be beneficial in the treatment of acute uncomplicated influenza A virus infection in adult patients, according to the results of a Phase 2b study.

To evaluate the safety and antiviral activity of the treatment, patients in the TOPAZ trial (N=292) were randomized to receive pimodivir 300mg or 600mg, pimodivir 600mg plus oseltamivir 75mg, or placebo twice daily for 5 days; of the 292 patients included, 223 had confirmed influenza A and were treated.

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Results showed that in patients with acute uncomplicated influenza A virus infection, pimodivir, both as monotherapy and in combination with oseltamivir, was associated with significant virologic improvements vs placebo. Moreover, the combination of pimodivir plus oseltamivir was found to result in the largest decrease in viral load. The most commonly reported adverse events were diarrhea and nausea, which were mild to moderate in severity; overall, the treatment was well-tolerated.

“While only trends toward a clinical benefit were observed in this study, owing to a low power to detect statistically significant differences, these trends, along with the favorable safety and dosing profiles, provide an overall compelling case for further investigation,” concluded the authors.

For more information visit academic.oup.com.

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HCV Therapy Linked to Lowered Threat of Incident CVD Occasions

 
Both the incidence rate as well as risk factors for CVD events were assessed

Both the incidence rate as well as risk factors for CVD events were assessed

The risk of incident cardiovascular disease (CVD) events appears to be lower in hepatitis C virus (HCV) infection patients receiving direct-acting antiviral (DAA) regimens compared with those receiving older pegylated interferon-based therapy or no treatment at all, according to a study presented at the Liver Meeting 2018.

ERCHIVES (Electronically Retrieved Cohort of HCV Infected Veterans) was utilized to identify all patients who received HCV treatment for at least 7 weeks as well as a propensity-score matched group who did not receive treatment. Each group included 32,575 patients. Patients with HIV, HBV, or previously diagnosed CVD were excluded from the study. Both the incidence rate (per 1000 person-years) as well as risk factors for CVD events were assessed. 

“The incidence rate for CVD events/1,000 person-years (95% CI) among the treated was 19.10 (17.79, 20.50) vs. 32.37 (30.51, 34.33) among the untreated (P<.01),” the study authors reported. Results of the study also found that patients receiving DAA therapy had a lower risk of incident CVD events compared with those receiving pegylated interferon/ribavirin (HR: 0.68; 95% CI: 0.53, 0.88). Additionally, patients who achieved sustained virologic response (SVR) also had a lower risk of incident CVD events (HR: 0.76; 95% CI: 0.63, 0.92). “Kaplan-Meier curves demonstrated that untreated persons had a shorter CVD event-free survival during 30 months of follow-up compared with the treated persons,” the study authors added.

Results of this study determined that the likelihood of incident CVD events was not only reduced in HCV patients treated with DAA therapy, but also for patients who attained SVR.