HomeSerzoneBest antidepressant for teens? (STIMULANTS)?
Posted in Serzone on 22nd April 2014

Best antidepressant for teens? (STIMULANTS)?
I’m researching various kinds of antidepressants to suggest to my doctor.
In your experience, which antidepressant has helped you the most with anxiety/depression?
Please give me some good stimulants that boost serotonin levels in your brain. (Similar to Ritalin and Wellbutrin)
Thank you so much.

Best answer(s):

Answer by Mathieu
There is no “best” antidepressant, it depends on the severity and type of depression (eg., endogenous, atypical, melancholic, anxious) and/or the severity and type of anxiety (eg., generlized anxiety, panic disorder, social anxiety disorder). Typically Prozac (fluoxetine) is the preferred antidepressant in teens but any of them can be used.

All antidepressant increase levels of one or more monoamine (serotonin, dopamine, norepinephrine). The most common antidepressants are selective serotonin reuptake inhibitors (SSRIs) and include Celexa (citalopram), Lexapro, Cipralex (escitalopram), Luvox (fluvoxamine), Paxil (paroxetine), Prozac (fluoxetine), and Zoloft (sertraline). SSRIs all increase serotonin and have no clinically significant effects on other neurotransmitters.

Cymbalta (duloxetine), Effexor (venlafaxine), and Pristiq (desvenlafaxine) are serotonin-norepinephrine reuptake inhibitors (SNRIs) so they act on both serotonin and norepinephrine.

SSRIs and SNRIs are the most commonly used antidepressants and are typically the first-line treatments.

The other major types of antidepressants are tricyclic antidepressants (TCAs) and include Sinequan (doxepin), Anafranil (clomipramine), Elavil (amitriptyline), Aventyl, Pamelor (nortriptyline), and Tofranil (imipramine).

TCAs act on serotonin and norepinephrine but unlike SNRIs these medications effect many other neurotransmitters which is why they tend to have more side effects but they are also often more effective in some people.

There are antidepressants often called novel antidepressants because most are very unique and have few other drugs in its class. Novel antidepressants include Desyrel (trazodone), Remeron (mirtazapine), Serzone (nefazodone), and Wellbutrin (bupropion).

Wellbutrin is very commonly used for depression however the other novel antidepressants are not used nearly as often. Wellbutrin is the only antidepressant with significant effects on dopamine and it is an antidepressant that is typically best for people with depression without anxiety although it can help with anxiety.

The least commonly used– and oldest– antidepressants are monoamine oxidase inhibitors (MAOIs) and include Nardil (phenelzine), Parnale (tranylcypromine), Eldepryl (selegiline), Emsam (selegiline transdermal) and Marplan (isocarboxazid).

MAOIs work in a way completely different from all the other antidepressants and are typically only used in severe cases of depression unresponsive to several other medications.

Also Ritalin (methylphenidate) is NOT has an antidepressant and it has a different mechanism of action. Ritalin has little or no effect on serotonin but it does increase dopamine and norepinephrine. Amphetamine stimulants (Adderall, Dexedrine, Vyvanse, Desoxyn) act on all three neurotransmitters. These medications are sometimes used for depression but typically they are only prescribed for treatment resistant (refractory) major depressive disorder, depression associated with or comorbid with significant physical illness especially cancer or AIDS, and for depression with severe hypersomnia (excessive sleepiness) that is not controlled with antidepressants.

My advice is to let your doctor decide what the best medication for you is- all of them work and all of them work differently for different people. Also many antidepressants are NOT stimulating, just because serotonin is increased does not mean it will increase energy.

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